Microsoft Outlook Won't Open. Step 1. Press the Shift, Ctrl and Esc keys to open the Windows Task Manager. Step 2. Open the "Processes" tab. Rummage the processes list to see if the Microsoft Outlook process is running. If it is, click the process. Step 3. Click "End Process." Exit the Task Manager. ...

After updating to Current Channel Version 1905 (Build 11629.20196) and higher, Outlook may hang at loading profile or won't start. You may notice that if you open Task Manager that other Office processes are unexpectedly listed even though you did not open the application. If you end those processes it may enable Outlook to then open normally.

Hello IdahoJulie, I suggest to you check for windows updates then try to open outlook in safe mode again, if it still without opening I suggest to create a new windows profile with local admin permissions and check if open in safe mode then disable add-ins. I hope it helps. Liliana De Freitas.

The “Microsoft Outlook Won’t Open” error is just another such occurrence. If the methods we told you about haven’t worked then our last piece of advice to you is this: contact Microsoft and let them know what your problem is.

Restart. Choose Start > Run, and in the Open box, type Outlook. Note: If the program loads properly, it's likely that one of your add-ins is the source of the error and you need to identify which one. To determine which add-in is the problem, enable one add-in at a time.

To open Outlook in Safe mode: Close Outlook then hold Ctrl as you click on the Outlook icon. You'll get a message asking if you want to start in Safe mode.