The Substance: Directed by Coralie Fargeat. With Demi Moore, Margaret Qualley, Dennis Quaid, Edward Hamilton-Clark. A fading celebrity takes a black-market drug: a cell-replicating substance that temporarily creates a younger, better version of herself.

In a rage of desperation, she calls a number that’s been handed to her anonymously and gets hooked up with a sinister sci-fi body-enhancement program known as The Substance.

Demi Moore & Margaret Qualley deliver perfect performances in The Substance. The film dissects and confronts impossible beauty standards with humor and horror. Dennis Quaid shines in an exceptional fun performance in this audacious body horror epic.

Demi Moore and Margaret Qualley star as two women who switch bodies after injecting a mysterious drug that promises youth and beauty. The Substance is a bloody, bonkers, and unsubtle satire of the beauty industry and its effects on women.

In The Substance, the much-discussed, opulently stylised and lavishly gory gonzo horror from French director, Coralie Fargeat, a disembodied voice playing over a marketing video for a tenebrous...

In The Substance, Demi Moore plays an aerobics TV star who turns 50 and is promptly ousted from her gig in Hollywood. She and Margaret Qualley duke it out in this excruciating body horror tale.

Coralie Fargeat's satirical body horror The Substance, which stars Demi Moore and Margaret Qualley, will have audiences "gasping, wincing, and laughing in disbelief".