The Saints are the Panthers' divisional and regional rivals, as they both play in the NFC South and have similar fan bases in the Carolinas and Louisiana. The Saints have a slight edge in the all-time series, 27-25, and have won the last four meetings.
The Buccaneers are another divisional rival of the Panthers, as they also play in the NFC South. The Panthers have a 24-16 advantage in the all-time series, but the Buccaneers have won the last three games, including a playoff victory in 2020.
The Falcons are the third divisional rival of the Panthers, as they also play in the NFC South. The Falcons lead the all-time series, 32-19, and have won six of the last seven games. The rivalry is also marked by some memorable games, such as the 2003 NFC Divisional Round and the 2015 season finale.
The Seahawks are a non-divisional rival of the Panthers, as they play in the NFC West. The Seahawks have dominated the series, 10-4, and have won six of the last seven games, including two playoff games in 2005 and 2014. The rivalry is fueled by the similar style of play and personnel of both teams, as well as some close and controversial games.
The Broncos are a non-conference rival of the Panthers, as they play in the AFC West. The Broncos have a 5-1 edge in the series, and have won the last four games, including the Super Bowl 50 in 2016. The rivalry is based on the disparity of success and the contrast of offense and defense between the two teams.